- Hrithik Roshan as Vijay Deenanath Chauhan, a man seeking to avenge the murder of his father.
- Rishi Kapoor as Rauf Lala, an underworld Don. He runs a meat business and simultaneously deals in drugs and prostitution.
- Sanjay Dutt as Kancha Cheena. An unscrupulous man, often mocked for his hairless appearance; he runs Mandwa as a concentration camp and exploits the villagers in order to deal in cheap cocaine.
- Om Puri as Commissioner Gaitonde. He is a brutally honest cop who develops a close bond with Vijay.
- Priyanka Chopra as Kaali Gawde, a talkative girl. She loves Vijay and provides moral support in his quest for revenge.
- Zarina Wahab as Suhasini Chauhan, Vijay's mother. She tries hard to dissuade Vijay against choosing a path of violence.
- Chetan Pandit as Master Deenanath Chauhan, Vijay's father. A morally upright man, he is wrongly framed for the rape and murder of a young girl and is subsequently killed by Kancha.
- Sachin Khedekar as Mr. Borkar. He is the Home Secretary of Maharashtra and an aide of Kancha.
- Rajesh Tandon as Mazhar Lala, Rauf Lala's elder son. He is suspicious of Vijay's loyalties.
- Deven Bhojani as Azhar Lala, a mentally challenged younger son of Rauf Lala.
- Rajesh Vivek as Mr. Bakshi, a police inspector who doubles as Kancha's informer.
- Banwarilal Taneja as Kancha's father.
- Ravi Jhankal as Shantaram, Kancha's aid who conspires with Vijay.
- Kanika Tiwari as Shiksha Deenanath Chauhan, Vijay's sister. She lives with her mother and is unaware of Vijay's existence.
- Pankaj Tripathi as Surya.
- Brijendra Kala as Muneem.
- Katrina Kaif as "Chikni Chameli" (special appearance).
- Madhurjeet Sarghi as Lachhi, Kaali's mother.
- Arish Bhiwandiwala as the younger Vijay Chauhan.
- Vraddhi Sharma as a journalist.
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